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What are Reversible and Irreversible Changes when Masculinizing with Testosterone?

Testosterone or T is an essential part of HRT regimen for those seeking to masculinize.

There are different formulations of T. The form and dose of T is determined by your medical provider. Your personal needs, as well as any medical or mental health conditions, are some of the factors to consider.

Testosterone can be taken by:

  • injection (intramuscular or subnormal)

  • implanted pellets,

  • or transdermally via skin patch/creams/gels

And if you are planning on starting HRT, I recommend checking out my comprehensive resource page for a provider.

Each person responds to T differently. It’s difficult to predict how quickly the changes will take place for you. That’s why microdosing on T is tricky for nonbinary individuals.

Let’s get the bad news out of the way. I am referring to things T will NOT change. A concerning question for many.

IRREVERSIBLE CHANGES (things T WON’T change)

  • Height.

  • Reduction in breast/chest size or density.

  • Prevent pregnancy.

  • Protect against sexually transmitted diseases.

PERMANENT CHANGES

  • Increased hair growth on the face, arms, legs, chest, back and abdomen.

  • Hair loss, especially at the temples and crown of the head and, possibly, becoming completely bald.

  • Deepened voice.

  • Enlargement of the clitoris.

  • Thickening of some facial bone structure.

Now let’s take a look at reversible changes. Keep in mind, that these may change back if you stop taking T. While mostly reversible, even these changes vary from person to person.

REVERSIBLE CHANGES

  • Increased libido and changes in sexual behavior similar to those experienced at puberty.

  • Increased muscle mass.

  • Decreased fat in the breasts, buttocks and thighs.

  • Increased fat in the abdomen.

  • Increased sweat and changes in body odor.

  • Increased appetite, weight gain, and fluid retention.

  • Prominence of veins and coarser skin.

  • Acne of the face, back, and chest, especially in the first few years of treatment, which, if severe, may cause permanent scarring.

  • Stopping of menstruation.

  • Vaginal atrophy, dryness and itching that may occasionally cause pain with vaginal penetration.

  • Changes in mood and emotional stability.

Masculinizing effects of T take several months to become noticeable. It can take up to five or more years to reach their maximum effects! And there is no way to predict how fast your body will change or react to T.

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